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London, Sarah

One or more keywords matched the following properties of London, Sarah

Property	Value
keywords	development, learning & memory, epigenetics, genomics, molecular signaling, critical period
overview	We still don’t know what properties of the brain promote and limit the ability to learn although behaviorally, we observe individual, sex, and age differences in the long-term effects of experience. Memory formation requires that two major levels of neurobiology are coordinated 1) the presence of a subset of cells, or "ensemble," that are capable of participating in memory storage and 2) the triggering of appropriate molecular and genomic changes in response to experience. The challenges of placing molecular underpinnings of neural plasticity within cell populations that are engaged in memory formation are compounded by the need to behaviorally link cellular and molecular brain properties to the ability to learn. In the London Lab, we take advantage of a model system that has a Critical Period for sensory learning, the zebra finch songbird, to discover how epigenetic mechanisms, genomic regulation, molecular signaling, and cell subtypes contribute to the ability to learn complex natural behaviors. Because Critical Periods define restricted phases in development when an experience is optimally encoded in ways that have long-term consequences on brain function and behavioral patterns, we can meaningfully link neural properties before, during, and after the Critical Period to behavioral outcomes.

Property

Value

keywords

development, learning & memory, epigenetics, genomics, molecular signaling, critical period

overview

We still don’t know what properties of the brain promote and limit the ability to learn although behaviorally, we observe individual, sex, and age differences in the long-term effects of experience. Memory formation requires that two major levels of neurobiology are coordinated 1) the presence of a subset of cells, or "ensemble," that are capable of participating in memory storage and 2) the triggering of appropriate molecular and genomic changes in response to experience. The challenges of placing molecular underpinnings of neural plasticity within cell populations that are engaged in memory formation are compounded by the need to behaviorally link cellular and molecular brain properties to the ability to learn. In the London Lab, we take advantage of a model system that has a Critical Period for sensory learning, the zebra finch songbird, to discover how epigenetic mechanisms, genomic regulation, molecular signaling, and cell subtypes contribute to the ability to learn complex natural behaviors. Because Critical Periods define restricted phases in development when an experience is optimally encoded in ways that have long-term consequences on brain function and behavioral patterns, we can meaningfully link neural properties before, during, and after the Critical Period to behavioral outcomes.

One or more keywords matched the following items that are connected to London, Sarah

Item Type	Name
Concept	Neural Pathways
Concept	Gene Expression Regulation, Developmental
Academic Article	Steroidogenic enzymes along the ventricular proliferative zone in the developing songbird brain.
Academic Article	Neural expression and post-transcriptional dosage compensation of the steroid metabolic enzyme 17beta-HSD type 4.
Academic Article	Developmental shifts in gene expression in the auditory forebrain during the sensitive period for song learning.
Academic Article	Functional identification of sensory mechanisms required for developmental song learning.
Academic Article	Developmental song learning as a model to understand neural mechanisms that limit and promote the ability to learn.
Academic Article	Influences of non-canonical neurosteroid signaling on developing neural circuits.
Academic Article	Genomic and neural analysis of the estradiol-synthetic pathway in the zebra finch.
Academic Article	Epigenetic regulation of transcriptional plasticity associated with developmental song learning.
Academic Article	Shared neural substrates for song discrimination in parental and parasitic songbirds.
Academic Article	Birdsong and the neural production of steroids.
Academic Article	Cloning of the zebra finch androgen synthetic enzyme CYP17: a study of its neural expression throughout posthatch development.
Academic Article	Interhemispheric functional connectivity in the zebra finch brain, absent the corpus callosum in normal ontogeny.
Academic Article	Inhibitory cell populations depend on age, sex, and prior experience across a neural network for Critical Period learning.
Academic Article	Experience selectively alters functional connectivity within a neural network to predict learned behavior in juvenile songbirds.
Grant	Developmental Differences in Brain Androgen Synthesis
Grant	Mechanisms of age- and experience-dependent neural plasticity and behavior
Grant	The molecular basis for developmental sensory learning
Grant	At the right time and place ? identifying epigenetic and molecular determinants of a developmental learning window

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Neural
development